產(chǎn)品詳情
Cat#:203P16
序列(三字母):3,5-Difluorophenylacetyl-Ala-Phg-OMe
序列(單字母):3,5-Difluorophenylacetyl-A-Phg-OMe
類似名:DAPM
分子式:C??H??F?N?O?
分子量:390.39
CAS#:208255-51-0
合成方法:Synthetic
存儲條件:-20 ± 5 °C
應(yīng)用:Alzheimer´s Disease
描述:DAPM, a cell-permeable γ-secretase inhibitor with anti-aggregation properties that dose-dependently inhibits amyloid β-protein (Aβ) secretion in 7PA2 Chinese hamster ovary (CHO) cells with an half-maximal inhibitory concentration of IC?? ~ 10 nM. DAPM prevents oligomer formation by selectively blocking the Aβ dimer and trimer formation at doses that allow appreciable monomer production.
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