/Secretase Inhibitors and Substrates (24)
/H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH
產(chǎn)品詳情
Cat#:203P18
序列(三字母):H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH
序列(單字母):ELD[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]AEF
分子式:C??H??N?O??
分子量:908.02
CAS#:1349991-28-1
合成方法:Synthetic
存儲條件:-20 ± 5 °C
應(yīng)用:Alzheimer´s Disease
描述:Glu-Leu-Asp-Leu-psi[CHOH-CH?]-Ala-Ala-Glu-Phe (ELDL-psi[CHOH-CH?]-AAEF), a potent inhibitor for human brain memapsin-2 (β-secretase) with a Ki-value of 0.3 nM. The hydroxyethylene isostere of the Leu-Ala motif functions as a mimic of the transition state.
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